HLA genes, immunoglobulin genes and human disease

Understanding how combinations of HLA and KIR genes influence disease

Combinations of HLA and killer cell immunoglobulin-like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA-KIR ge...

Structure and expression of the human immunoglobulin lambda genes

We determined the DNA sequence of two large regions of chromosome 22: 33.7 kb containing the C lambda complex; and 5.2 kb 5' of the functionally rearranged lambda gene from the human myeloma, U266. Analysis of these sequences reveals the complete structure of the human C lambda complex and a previously undescribed seventh C lambda region that may encode the Ke+Oz- lambda protein. The seven cons...

Structure and Expression of the Human Immunoglobulin X Genes

We determined the DNA sequence of two large regions ofchromosome 22 : 33.7 kb containing the Ct, complex; and 5 .2 kb 5' of the functionally rearranged X gene from the human myeloma, U266. Analysis of these sequences reveals the complete structure of the human Cr complex and a previously undescribed seventh Cx region that may encode the Ke+OzX protein . The seven constant regions are organized ...

Split immunoglobulin genes and human heavy chain deletion-mutants.

Localization, analysis and evolution of transposed human immunoglobulin V" genes

The localization of V", gene regions to chromosome 2, on which the K locus is located, and to other chromosomes is described. The V", genes that have been transposed to other chromosomes are called orphons. The finding of two new V", genes on chromosome 22 is reported. A V", 11 gene of this region and two V", I genes of the Chr 1 and the cos 118 regions were sequenced. The two V", I orphon sequ...